Mechanistically quantifies protein functions
High specificity and dynamic range (spectroscopic value)
Spatially maps these functions in tissue and cells
Spatial mapping and multiplexing
Fully compatible with regular laboratory workflows
Robust, unbiased and reproducible
Higher signal-to-noise ratio
Proven clinical cut-off values in IO
QF-Pro® (Quantitative Function of Proteins) is a novel bio-imaging technology that spatially quantifies protein function, such as protein-protein interactions and protein post-translational modifications in cells and fixed tissue (FFPE) samples. QF-Pro® is based on a perfected and simplified version of the FRET/FLIM technology that has been tailored for ease-of-use in biology labs. It comprises the bespoke Violet 3.0 imaging platform and a versatile reagents' kit for FRET.
| IHC/IF | Proximity Ligation Assay | QF-Pro® | |
|---|---|---|---|
| Quantifies protein function | + | ++ | +++ |
| Sensitivity | − | + | +++ |
| Specificity | − | + | +++ |
| Clinical Value* | + | − | +++ |
*For predicting response to α-PD-1/PD-L1 therapies in NSCLC
Label samples using primary antibodies and specialized QF-Pro® secondary reagents for precise protein detection.
Spatial protein distribution and lifetime map
Analyze protein interactions with the advanced Violet 3.0 imaging platform, providing comprehensive spatial protein distribution and lifetime mapping capabilities.
One Kit, Any Biomarker
Potential amplification reagents bring unmatched quantification to functional proteomics
Compatible with any fixed sample including FFPE tissues and cells
Includes secondary labeling reagents, quenching buffers, and signal amplification components for a streamlined workflow
Enables multiplexing of functional proteomics scales and biomarker expression profiles within a single sample
Smart FLIM, Instant Read-Outs
Compact benchtop FLIM fits seamlessly into any laboratory space
Maintenance-free, reliable, continuous operation with no downtime or upkeep requirements
Delivers 4 biomarker expression profiles plus 1 functional QF-ɸ-evt map in a single read-out
Next-Gen System, automated, highly robust, and high throughput
Streamlined Analysis, Functional Proteomics Unlocked
User-friendly interface, intuitive design for effortless navigation
End-to-end imaging solution combining acquisition and analysis in a single workflow
Cross-platform compatibility, interoperable with files from other FLIM devices
