Cancer & Disease Mechanism Research
Explore cellular and subcellular interactions that shape health and disease like never before.
Extract all proteomic information without antibodies or targeted panels across an entire sample.
350 nm precision at sub-cellular scale.
Use with FFPE/fresh frozen tissue samples or fixed cells.
Discover novel biomarkers or therapeutic targets of disease-associated locations.
Discover low copy number proteins from increased dynamic range due to subcellular protein isolation.
Novel proteomes of organelles, cells and organisms.
Two photon guided photo-biotinylation identifies only proteins in regions of interest.
Traditional proteomic technology often relies on predefined panels or antibody-based enrichment,
which introduces bias—only known or expected proteins are detected.
But Syncell’s Microscoop® labels and analyzes all proteins in a specific region of interest
without pre-selection, allowing mass spec to capture low-abundance or rare proteoforms, and reveal
otherwise unknown protein constituents with higher dynamic range and specificity than laser
microdissection or proximity labeling methods.
Mass spec alone doesn’t provide spatial information, but combining it with Syncell’s microscopy-guided photo-biotinylation technology enables researchers to link spatial location with the entire local proteome, allowing you to:
By restricting proteomic analysis to defined cellular or subcellular regions, our proprietary opto-proteomic platform improves:
Microscoop® works with FFPE and fresh frozen tissue, preserving the integrity of archived clinical samples. This opens MS-based insights in areas where methods like proximity labeling cannot operate:
See Biology Like Never Before
Our advanced technology enables precise localization of proteins within cellular compartments, revealing intricate molecular interactions and pathways.
Explore the proteome without preconceived hypotheses, identifying novel biomarkers and therapeutic targets through comprehensive spatial analysis.
Integrate high-resolution imaging with proteomic data to correlate morphological features with molecular expression patterns.
Streamline your research with our end-to-end automated solutions, from sample preparation to data analysis and visualization.
This streamlined process is designed to deliver comprehensive and actionable data from complex biological samples, ensuring high quality and resolution at every stage.
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Precise tissue handling and preparation, followed by high-throughput data acquisition, ensures the integrity of the proteome for downstream analysis.
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Raw data is rigorously filtered, normalized, and aligned using proprietary algorithms to maximize feature detection and ensure accurate quantification.
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In-depth statistical analysis is performed to identify differentially expressed proteins and quantify their abundance across various sample cohorts.
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The resulting protein lists are mapped to functional pathways and processes, generating a clear, comprehensive report for actionable biological insights.
High-throughput analysis across multiple cells and tissue regions.
Real-time visualization and protein mapping.
Compatibility with advanced proteomics workflows.
Comprehensive integration of spatial and molecular data.
Powerful Performance in an Entry-Level System
Microscoop® redefines proteomics by merging microscopy and protein discovery into a single platform. It allows scientists to uncover cellular and molecular complexity at a depth never before possible, driving breakthroughs in disease research, drug discovery, and systems biology.
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